Our lab uses the model organism C. elegans to study two sets of biological processes that involve developmental regulation of gene expression. We are investigating conserved mechanisms that defend against oxidative and other stresses, and how they contribute to development and longevity. We also study specialized mechanisms that regulate broad gene expression programs in the germline and early embryo, as models for stem cell biology.
The Blackwell lab is located at the Joslin Diabetes Center, in the Longwood Medical Area in Boston. Research laboratories at Harvard Medical School, Brigham and Women's Hospital, Beth Israel-Deaconess Medical Center, Children's Hospital, and Dana-Farber Cancer Center are only a short walk away, and provide a variety of research interactions, facilities, and seminars. We regularly participate in shared group meetings at Joslin Diabetes Center and the Harvard Stem Cell Institute, and in the Boston Area Worm Meeting. These and many regular seminar series provide important vehicles for interactions and collaborations.