Harvard Medical School Joslin Diabetes Center Harvard Stem Cell Institute

Publications

Listing of articles indexed on PubMed
  1. Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M. (2015) SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radic Biol Med. 88:290-301. [PDF]
  2. Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE, Dreyfuss JM, Hourihan JM, Raghavan P, Operaña TN, Esmaillie R, Blackwell TK. (2015) Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. eLife 4:e07836. [PDF]
  3. Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK. (2015) Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. 519:97-101. [PDF]
  4. Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK. (2014) Dietary restriction involves NAD+ -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell (Sep 25). [PDF]
  5. Mizunuma M, Neumann-Haefelin E, Moroz N, Li Y, Blackwell TK. (2014) mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity. Aging Cell 13:869-78. [PDF]
  6. Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. (2014) GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A 111:3781-6. [PDF]
  7. Glover-Cutter KM, Lin S, Blackwell TK. (2013) Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLOS Genet 9(9):e1003701. [PDF]
  8. Ruf V, Holzem C, Peyman T, Walz G, Blackwell TK, Neumann-Haefelin E. (2013) TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development. Dev Biol 384:214-27. [PDF]
  9. Ishikado A, Sono Y, Matsumoto M, Robida-Stubbs S, Okuno A, Goto M, King GL, Blackwell TK, Makino T. (2013) Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans. Free Radic Biol Med 65:1506-15. [PDF]
  10. Paek J, Lo JY, Narasimhan SD, Nguyen TN, Glover-Cutter K, Robida-Stubbs S, Suzuki T, Yamamoto M, Blackwell TK, Curran SP. (2012) Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Cell Metab 16:526-37. [PDF]
  11. Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR. (2012) Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab 16:336-47. [PDF]
  12. Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK. (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab 15:713-24. [PDF]
  13. Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, Blackwell TK. (2011) Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLOS Genet 7(6). [PDF]
  14. Wang J*, Robida-Stubbs S*, Tullet JM, Rual JF, Vidal M, Blackwell TK. (2010) RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. PLOS Genet 6(8). [PDF]
  15. Porter Abate J, Blackwell TK. (2009) Life is short, if sweet. Cell Metab 10:338-9. [PDF]
  16. Oliveira RP*, Porter Abate J*, Dilks K*, Landis J, Ashraf J, Murphy CT, Blackwell TK. (2009) Condition-adapted stress and longevity gene regulation by Caenorhabditits elegans SKN-1/Nrf. Aging Cell 8:524-41. [PDF]
  17. Hammel CM, Lubin I, Boag PR, Blackwell TK, Ambros V. (2009) nhl-2 Modulates microRNA activity in Caenorhabditis elegans. Cell 136:926-38. [PDF]
  18. Oláhová M, Taylor SR, Khazaipoul S, Wang J, Morgan BA, Matsumoto K, Blackwell TK, Veal EA. (2008) A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proc Natl Acad Sci U S A 105:19839-44. [PDF]
  19. Blackwell TK, Walker AK. (2008) OMA-gosh, where's that TAF? Cell 135:18-20. [PDF]
  20. Gartner A, Boag PR, Blackwell TK. (2008) Germline survival and apoptosis. WormBook doi:10.1895/wormbook.1.145.1. [PDF]
  21. Boag PR, Atalay A, Robida S, Reinke V, Blackwell TK. (2008) Protection of specific maternal messanger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis. J Cell Biol 182:543-57. [PDF]
  22. Tullet JM*, Hertweck M*, An JH*, Baker J, Hwang JY, Lui S, Oliveira RP, Baumeister R, Blackwell TK. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132:1025-38. [PDF]
  23. Blackwell TK, Walker AK. (2006) Transcription mechanisms. Wormbook. [PDF]
  24. Salinas LS, Maldonado E, Macias-Silva M, Blackwell TK, Navarro RE. (2007) The DEAD box RNA helicase VBH-1 is required for germ cell function in C. elegans. Genesis 45:533-46. [PDF]
  25. Walker AK, Boag PR, Blackwell TK. (2007) Transcription reactivation steps stimulated by oocyte maturation in C. elegans. Dev Biol 304:382-93. [PDF]
  26. Lehtinen MK, Yuan Z, Boag PR, Villen J, Becker EBE, DiBacco S, Yang Y, Gygi S, Blackwell TK, Bonni A. (2006) A conserved MST-FOXO signaling pathway mediates oxidative stress responses and extends lifespan. Cell 125:987-1001. [PDF]
  27. An JH, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, Blackwell TK. (2005) Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A 102:16275-80. [PDF]
  28. Boag PR, Nakamura A, Blackwell TK. (2005) A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans. Development 132:4975-86. [PDF]
  29. Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, Blackwell TK, Matsumoto K. (2005) The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev 19:2278-83. [PDF]
  30. Navarro RE, Blackwell TK. (2005) Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1. Genesis 42:172-80. [PDF]
  31. Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman JP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege, FC, Jaehning JA, Kim Y-J, Kuras L, Achim L, Lis JT, Meisterernest M, Naar A, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD. (2004) A Unified Nomenclature for Protein Subunits of Mediator Complexes Linking Transcriptional Regulators to RNA Polymerase II. Mol Cell 14:553-57. [PDF]
  32. Wang JC, Walker AK, Blackwell TK, Yamamoto KR. (2004) The Caenorhabditis elegans ortholog of TRAP 240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J Biol Chem 279:29270-7. [PDF]
  33. Blackwell TK. (2004) Germ cells: Finding programs of mass repression. Curr Biol 14:R229-30. [PDF]
  34. Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WFC, Blackwell TK, Anderson P. (2004) MK-2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J 23:1313-24. [PDF]
  35. Walker AK, Shi Y, Blackwell TK. (2004) An extensive requirement for TFIID-specific TAF-1 in C. elegans embryonic transcription. J Biol Chem 279:15339-47. [PDF]
  36. Blackwell TK, Walker AK. (2003) Transcription elongation: TLKing to chromatin? Curr Biol 13:R915-6. [PDF]
  37. Shi Y, Blackwell TK. (2003) A two-tiered transcription regulation mechanism that protects germ cell identity: lessons from the worm. Mol Cell 12:1062-64. [PDF]
  38. An JH, Blackwell TK. (2003) SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev 17:1882-93. [PDF]
  39. Zhang F, Barboric M, Blackwell, TK, Peterlin, BM. (2003) A model of repression: CTD analogs, and PIE-1 inhibit transcriptional elongation by P-TEFb. Genes Dev 17:748-58. [PDF]
  40. Takagi T, Walker AK, Sawa C, Diehn F, Takase Y, Blackwell TK, Buratowski S. (2003) The Caenorhabditis elegans mRNA 5'-capping enzyme: In vitro and in vivo characterization. J Biol Chem 278:14174-84. [PDF]
  41. Walker AK, Blackwell TK. (2003) A broad but restricted requirement for TAF-5 (hTAFII100) for embryonic transcription in C. elegans. J Biol Chem 278:6181-6. [PDF]
  42. Shim EY, Walker AK, Shi Y, Blackwell TK. (2002) CDK-9/Cyclin T (P-TEFb) is required in two post-initiation pathways for transcription in the C. elegans embryo. Genes Dev 16:2135-46. [PDF]
  43. Shim EY, Walker AK, Blackwell TK. (2002) Broad requirement for the Mediator subunit RGR-1 for transcription in the C. elegans embryo. J Biol Chem 277:30413-16. [PDF]
  44. Johnson BA, Blackwell TK. (2002) Multiple tristetraprolin sequence domains required to induce apoptosis and modulate responses to TNFα through distinct pathways. Oncogene 21:4237-46. [PDF]
  45. Blackwell TK, Walker A. (2002) Getting the right dose of repression. Genes Dev 16:769-72. [PDF]
  46. Johnson BA, Stehn J, Yaffe M, Blackwell TK. (2002) Cytoplasmic localization of Tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem 277:18029-36. [PDF]
  47. Walker AK, Rothman JH, Shi Y, Blackwell TK. (2001) Distinct requirements for C. elegans TAFIIs in embryonic transcription. EMBO J 20:5269-79. [PDF]
  48. Navarro RE, Shim EY, Kohara Y, Singson A, Blackwell TK. (2001) CGH-1: a conserved predicted RNA helicase required for gametogenesis and protection from physiological germline apoptosis in C. elegans. Development 128:3221-32. [PDF] [Cover]
  49. Walker AK, See R, Batchelder C, Kophengnavong T, Gronniger JT, Shi Y, Blackwell TK. (2000) A conserved transcription motif suggesting functional parallels between C. elegans SKN-1 and Cap ‘n’ Collar-related proteins. J Biol Chem 275:22166-71. [PDF]
  50. Johnson BA, Geha M, Blackwell TK. (2000) Similar but distinct effects of the Tristetraprolin/TIS11 immediate-early proteins on cell survival. Oncogene 19:1657-64. [PDF]
  51. Kophengnavong T, Michnowicz JE, Blackwell TK. (2000) Establishment of distinct MyoD, E2A, and Twist DNA binding specificities by different basic region-DNA conformations. Mol Cell Biol 20:261-72. [PDF]
  52. Kophengnavong T, Carroll AS, Blackwell TK. (1999) The SKN-1 amino terminal arm is a DNA specificity segment. Mol Cell Biol 19:3039-50. [PDF]
  53. De J, Lai WS, Thorn JM, Goldsworthy SM, Liu X, Blackwell TK, Blackshear PJ. (1999) Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression. Gene 228:133-45. [PDF]
  54. Batchelder C, Dunn, MA, Choy B, Suh Y, Cassie C, Shim EY, Shin TH, Mello C, Seydoux, G, Blackwell TK. (1999) Transcriptional repression by the Caenorhabditis elegans germline protein PIE-1. Genes Dev 13:202-12. [PDF]
  55. Carroll AS, Gilbert DE, Liu X, Cheung JW, Michnowicz JE, Wagner G, Ellenberger TE, Blackwell TK. (1997) SKN-1 domain folding and basic region monomer stabilization upon DNA binding. Genes Dev 11:2227-38. [PDF]
  56. Blackwell TK. (1995) Selection of protein binding sites from random nucleic acid sequences. Meth Enzymol 254:604-18. [PDF]
  57. Blackwell TK, Bowerman B, Priess J, Weintraub H. (1994) Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements. Science 266:621-8. [PDF]