selected publications by the Blackwell Lab, by date of appearance
click on the accompanying link to view a PDF version of the named article

2009

Hammel CM, Lubin I,Boag PR, Blackwell TK, Ambros V. nhl-2 Modulates microRNA activity in Caenorhabditis elegans. Cell. 2009 Mar 6;136(5):926-38. [download PDF]

Blackwell TK, Walker AK.OMA-gosh, where's that TAF? Cell. 2008 Oct 3;135(1):18-20. [download PDF]

Gartner A, Boag PR, Blackwell TK. Germline survival and apoptosis.WormBook, ed. The C. elegans Research Community, doi/10.1895/wormbook.1.145.1, [download PDF]Website: wormbook.org

Boag PR, Atalay A, Robida S, Reinke V, Blackwell TK. Protection of specific maternal messanger RNAs by the P body protein CGH-1 (Dhh1/RCK)during Caenorhabditis elegans oogenesis. J Cell Biol. 2008 Aug 11;182(3):543-57. [download PDF]

Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Lui S, Oliveira RP, Baumeister R, Blackwell TK. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 2008 Mar 21;132(6):1025-38. [download PDF]

Salinas LS,Maldonado E, Macias-Silva M,Blackwell TK, Navarro RE. The DEAD box RNA helicase VBH-1 is required for germ cell function in C. elegans. Genesis 2007 Sep; 45(9):533-46.

Walker AK, Boag PR, Blackwell TK. Transcription reactivation steps stimulated by oocyte maturation in C. elegans. Dev Biol. 2007 Apr 1;304(1):382-93. Epub 2006 Dec 23. [download PDF]

Lehtinen MK, Yuan Z, Boag PR, Villen J, Becker EBE, DiBacco S, Yang Y, Gygi S, Blackwell TK, Bonni A. A conserved MST-FOXO signaling pathway mediates oxidative stress responses and extends lifespan. Cell 125, 987-1001. [download PDF]

Walker AK, Blackwell TK. Transcription Mechanisms. Wormbook, ed. The C. elegans Research Community, doi/10.1895/wormbook.1.121.1. [download PDF] Website: wormbook.org

Navarro RE, Blackwell TK. Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1. Genesis 2005; 42:172-180. [download PDF]

Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, Blackwell TK, Matsumoto K. The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev 2005; 19:2278-83. [download PDF]

Boag PR, Nakamura A, Blackwell TK. A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans. Development 2005; 132:4975-86. [download PDF]

An JH, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, Blackwell TK. Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A 2005; 102:16275-80. [download PDF]

Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WFC, Blackwell TK, Anderson P. MK-2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO Journal 2004; 23:1313-1324. [download PDF]

Walker AK, Shi Y, Blackwell TK. An extensive requirement for TFIID-specific TAF-1 in C. elegans embryonic transcription. J Biol Chem 2004; 279:15339-47. [download PDF]

Wang J-C, Walker AK, Blackwell TK, Yamamoto KR. The Caenorhabditis elegans ortholog of TRAP 240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J Biol Chem 2004; 279:29270-7. [download PDF]

Blackwell TK. Germ cells: Finding programs of mass repression. Curr. Biol. 2004; 14:R229-30. [download PDF]

Bourbon H-M, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman JP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege, FC, Jaehning JA, Kim Y-J, Kuras L, Achim L, Lis JT, Meisterernest M, Naar A, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD. A Unified Nomenclature for Protein Subunits of Mediator Complexes Linking Transcriptional Regulators to RNA Polymerase II. Mol. Cell. 2004;14:553-57. [download PDF]


2003
An JH, Blackwell TK. SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev 2003; 17:1882-1893. [download PDF]

Shi Y, Blackwell TK. A two-tiered transcription regulation mechanism that protects germ cell identity: lessons from the worm. Mol. Cell. 2003;12:1062-1064. [download PDF]

Blackwell TK, Walker AK. Transcription elongation: TLKing to chromatin? Curr. Biol. 2003;13:R915-R916. [download PDF]

Zhang F, Barboric M, Blackwell, TK, Peterlin, BM. (2003) A model of repression: CTD analogs, and PIE-1 inhibit transcriptional elongation by P-TEFb. Genes Dev., 17, 748-758. [download PDF]

Takagi T, Walker AK, Sawa C, Diehn F, Takase Y, Blackwell TK, Buratowski S. (2003) The Caenorhabditis elegans mRNA 5'-capping enzyme: In vitro and in vivo characterization. J. Biol. Chem., 278, 14174-14184. [download PDF]

Walker AK, Blackwell TK. (2003) A broad but restricted requirement for TAF-5 (hTAFII100) for embryonic transcription in C. elegans. J. Biol. Chem., 278, 6181-6. [download PDF]


2002
Shim EY, Walker AK, Blackwell TK. (2002) Broad requirement for the Mediator subunit RGR-1 for transcription in the C. elegans embryo. J. Biol. Chem., 277, 30413-30416. [download PDF]

Shim EY, Walker AK, Shi Y, Blackwell TK. (2002) CDK-9/Cyclin T (P-TEFb) is required in two post-initiation pathways for transcription in the C. elegans embryo. Genes Dev., 16, 2135-2146. [download PDF]

Johnson BA, Blackwell TK. (2002) Multiple Tristetraprolin sequence domains required to induce apoptosis and modulate responses to TNF-α through distinct pathways. Oncogene, 21, 4237-4246. [download PDF]

Johnson BA, Stehn J, Yaffe M, Blackwell TK. (2002) Cytoplasmic localization of Tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J. Biol. Chem., 277, 18029-18036. [download PDF]

Blackwell TK, Walker A. (2002) Getting the right dose of repression. Genes Dev., 16, 769-772. [download PDF]


2001
Walker AK, Rothman JH, Shi Y, Blackwell TK. (2001) Distinct requirements for C. elegans TAFIIs in embryonic transcription. EMBO Journal, 20, 5269-5279. [download PDF]

Navarro RE, Shim EY, Kohara Y, Singson A, Blackwell TK. (2001) CGH-1: a conserved predicted RNA helicase required for gametogenesis and protection from physiological germline apoptosis in C. elegans. Development, 128, 3221-3232 (cover article). [download cover graphic]   [download PDF]


2000
Walker AK, See R, Batchelder C, Kophengnavong T, Gronniger JT, Shi Y, Blackwell TK. (2000) A conserved transcription motif suggesting functional parallels between C. elegans SKN-1 and Cap ‘n’ Collar-related proteins. J. Biol. Chem., 275, 22166-22171. [download PDF]

Johnson BA, Geha M, Blackwell TK. (2000) Similar but distinct effects of the Tristetraprolin/TIS11 immediate-early proteins on cell survival. Oncogene, 19, 1657-1664. [download PDF]

Kophengnavong T, Michnowicz JE, Blackwell TK. (2000) Establishment of distinct MyoD, E2A, and Twist DNA binding specificities by different basic region-DNA conformations. Mol. Cell. Biol., 20, 261-272. [download PDF]


1999
Kophengnavong T, Carroll AS, Blackwell TK. (1999) The SKN-1 amino terminal arm is a DNA specificity segment. Mol. Cell. Biol., 19, 3039-3050. [download PDF]


De J, Lai WS, Thorn JM, Goldsworthy SM, Liu X, Blackwell TK, Blackshear PJ. (1999) Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression. Gene 228, 133-145. [download PDF]

Batchelder C, Dunn, MA, Choy B, Suh Y, Cassie C, Shim EY, Shin TH, Mello C, Seydoux, G, Blackwell TK. (1999) Transcriptional repression by the Caenorhabditis elegans germline protein PIE-1. Genes Dev. 13, 202-212.[download PDF]


pre 1999
Carroll AS, Gilbert DE, Liu X, Cheung JW, Michnowicz JE, Wagner G, Ellenberger TE, Blackwell TK. (1997) SKN-1 domain folding and basic region monomer stabilization upon DNA binding. Genes Dev. 11, 2227-2238. [download PDF]

Blackwell TK. (1995) Selection of protein binding sites from random nucleic acid sequences. Meth. Enzymol. 254, 604-618.

Blackwell TK, Bowerman B, Priess J, Weintraub H. Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements. Science 1994; 266:621-8. [download PDF]